Endocrine Abstracts

Aim: To study prevalence of foot complications in patients on dialysis therapy and evaluate the role the haemodynamic changes during dialysis procedure in development of foot problems.Methods: 109 dialysis patients, mean age 49 years. 60 of them had diabetes mellitus (DM): 29 on haemodialysis (HD), 31 on peritoneal dialysis (PD). Non-diabetic patients (NDM): 24 HD, 25 PD.Vascular status: doppler, photoplethysmography. Polyneuropath...

Background: Testicular Adrenal Rest Tumors (TART) in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) or 11-hydroxylase deficiency (11OHD) are benign lesions causing testicular damage and infertility. We hypothesize that high ACTH exposure due to poor hormonal control during early life is promoting development of TART later in life.Objective: This study aims to examine the relation between early CAH diagnosis and cons...

Background: In 2019, the International CAH Registry (I-CAH) performed a benchmarking exercise of acute adrenal insufficiency related adverse events including adrenal crises (AC) and sick day episodes (SDE).Methods: In 2022, I-CAH data on children aged <18 years at first visit with 21-hydroxylase deficiency CAH from 35 centres in 19 countries were analysed to examine the current occurrence of SDE and AC and compared t...

Acromegaly is a rare endocrine disorder, caused by hypersecretion of growth hormone. Cardiovascular and metabolic complications reduce life expectancy. Early carbohydrate metabolism disorders and diabetes mellitus are frequently associated with acromegaly.Objective: The objective of this study was to evaluate the glycemic profile and cardiovascular complications in acromegaly.Methods: We performed a retrospective study. We included...

Introduction: Non-functioning pituitary tumors and primary empty sella are a common pathology within the differential diagnosis of pituitary masses. The manifestations will depend on the size of the tumor and the compression of adjacent structures being the most frequent neurological symptoms. Clinically the two entities are very similar and no clinical tools are known to be able to help the differential diagnosis.Objective: Perform a clinical and compar...

Objective: To know the pronostic value of serum thyroglobuline (Tg), obtained before thyroid ablation with I131, in order to predict cancer recurrence risk in patients treated with total thyroidectomy due to differentiated thyroid carcinoma (DTC).Methods: We conducted a computed search of the published literature in Medline. We included diagnostic test studies that evaluated the relationship between Tg before I131 ablation, with loc...

Objective: Tumor-induced osteomalacia is a rare paraneoplastic syndrome in which fibroblast growth factor 23 (FGF-23) hyperproduction by tumor causes renal phosphate wasting, severe hypophosphatemia and osteomalacia. Localization of the tumor can be a major diagnostic challenge.Material and methods: We present a clinical case concerning a 62-year old woman previously diagnosed with hypophosphatemic osteomalacia, with a slight improvement of clinical and ...

Background and aims: Current glycaemic treatment targets for women with gestational diabetes (GDM) are controversial. The aim of the study was to compare the effect of different intensities of glycaemic control in pregnant women with GDM on perinatal outcomes.Materials and methods: Pregnant women in the 8th to 31st week of gestation were randomly assigned to 2 groups per target glycaemic levels: GDM1 (very tight glycaemic targets, fasting blood glucose (...

In 2005, the evaluation of an international expert group* placed Bulgaria among those who successfully overcame the problem of ‘iodine deficiency’. The aim of the study is to assess the current iodine status in pregnant women in two main regions of Bulgaria - with a known iodine deficiency and other with sufficiency in the past.Material: A cross-sectional multicenter population-based study was conducted in a total of 84 settlements from the two...

Lipodystrophic syndromes are a heterogeneous group of usually rare disorders, which have in common the selective and irreversible deficiency of adipose tissue in the absence of nutritional deprivation or catabolic state. Clinically, they are characterized by insulin resistance, related to a state of hypoleptinemia, with manifestations such as polycystic ovarian syndrome, type 2 diabetes mellitus, severe hypertriglyceridemia, and steatohepatitis among their most frequent metabo...